Assessing the Competing Characteristics of Privacy and Safety within Vehicular Ad Hoc Networks

The introduction of Vehicle-to-Vehicle (V2V) communication has the promise of decreasing vehicle collisions, congestion, and emissions. However, this technology places safety and privacy at odds; an increase of safety applications will likely result in the decrease of consumer privacy. The National Highway Traffic Safety Administration (NHTSA) has proposed the Security Credential Management System (SCMS) as the back end infrastructure for maintaining, distributing, and revoking vehicle certificates attached to every Basic Safety Message (BSM). This Public Key Infrastructure (PKI) scheme is designed around the philosophy of maintaining user privacy through the separation of functions to prevent any one subcomponent from identifying users. However, because of the high precision of the data elements within each message this design cannot prevent large scale third-party BSM collection and pseudonym linking resulting in privacy loss. In addition, this philosophy creates an extraordinarily complex and heavily distributed system. In response to this difficulty, this thesis proposes a data ambiguity method to bridge privacy and safety within the context of interconnected vehicles. The objective in doing so is to preserve both Vehicle-to-Vehicle (V2V) safety applications and consumer privacy. A Vehicular Ad-Hoc Network (VANET) metric classification is introduced that explores five fundamental pillars of VANETs. These pillars (Safety, Privacy, Cost, Efficiency, Stability) are applied to four different systems: Non-V2V environment, the aforementioned SCMS, the group-pseudonym based Vehicle Based Security System (VBSS), and VBSS with Dithering (VBSS-D) which includes the data ambiguity method of dithering. By using these evaluation criteria, the advantages and disadvantages of bringing each system to fruition is showcased

Single-neuron dynamics in human focal epilepsy

Epileptic seizures are traditionally characterized as the ultimate expression of monolithic, hypersynchronous neuronal activity arising from unbalanced runaway excitation. Here we report the first examination of spike train patterns in large ensembles of single neurons during seizures in persons with epilepsy. Contrary to the traditional view, neuronal spiking activity during seizure initiation and spread was highly heterogeneous, not hypersynchronous, suggesting complex interactions among different neuronal groups even at the spatial scale of small cortical patches. In contrast to earlier stages, seizure termination is a nearly homogenous phenomenon followed by an almost complete cessation of spiking across recorded neuronal ensembles. Notably, even neurons outside the region of seizure onset showed significant changes in activity minutes before the seizure. These findings suggest a revision of current thinking about seizure mechanisms and point to the possibility of seizure prevention based on spiking activity in neocortical neurons

Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference

Homozygous Transthyretin Mutation in an African American Male

Cardiac amyloidosis of transthyretin type in the elderly may be senile or familial. The senile form is not typically associated with specific genetic changes. However, the familial form is and also occurs more frequently in African Americans than in the general population. One transthyretin mutation, V122I, is common in the African-American population, has a carrier frequency of 4%, and has marked cardiac specificity. Symptoms generally develop in the eighth and ninth decades. Here, we report the case of a 60-year-old African-American man who had a 2-year history of dyspnea and diffuse left ventricular wall thickening. Endomyocardial biopsy showed interstitial deposits of amorphous material confirmed as amyloid by Congo red staining and electron microscopy. Mass spectrometry showed a shift in protein mass of 14 d, indicative of transthyretin and confirming the production of abnormal protein. Bidirectional whole gene sequencing showed a homozygous mutation leading to a valine 122 isoleucine substitution (V122I). The 14-d mass shift observed using mass spectrometry is consistent with the V122I mutation. Homozygosity for the V122I mutation may be associated with earlier onset of cardiac disease. Transthyretin analysis should be considered for older African Americans with amyloid heart disease of transthyretin type

Conjugate observation of magnetospheric chorus propagating to the ionosphere by ducting

Whistler-mode chorus waves are critical for driving resonant scattering and loss of radiation belt relativistic electrons into the atmosphere. The resonant energies of electrons scattered by chorus waves increase at increasingly higher magnetic latitudes. Propagation of chorus waves to middle and high latitudes is hampered by wave divergence and Landau damping but is promoted otherwise if ducted by density irregularities. Although ducting theories have been proposed since the 1960’s, no conjugate observation of ducted chorus propagation from the equatorial magnetosphere to the ionosphere has been observed so far. Here we provide such an observation, for the first time, using conjugate spacecraft measurements. Ducted chorus waves maintain significant wave power upon reaching the ionosphere, which is confirmed by ray tracing simulations. Our results suggest that ducted chorus waves may be an important driver for relativistic electron precipitation